The Gambling Commission has announced the departure of chief executive Sarah Harrison at the end of February next year.
She is expected to take a up a senior role with the Department for Business, Energy and Industrial Strategy.
“I am proud of the work that all at the Commission have delivered together,” Harrison said.
“I am very confident that as the Commission delivers its new strategy it will go from strength to strength and will continue to make gambling in Britain fairer and safer.”
The commission’s chairman Bill Moyes said: “The Gambling Commission has set an ambitious agenda and clear priorities for treating customers fairly and making play safer and our new three-year strategy embeds this approach for the future.
“Sarah’s impact has been significant in shaping this direction of travel. I and my Board colleagues wish Sarah every success for the future and look forward to continuing to work with her to deliver this agenda over the next few months.”
While the commission seeks a successor, chief counsel and executive director Neil McArthur will take the helm after Harrison’s departure until a permanent CEO can take over.